Palliative Sedation at the End of Life: Patterns of Use in an Israeli Hospice

Am J Hosp Palliat Care. 2016 May;33(4):369-73. doi: 10.1177/1049909115572991. Epub 2015 Feb 20.

Abstract

Palliative sedation (PS) is indicated for refractory symptoms among dying patients. This retrospective descriptive study examines PS in an Israeli hospice. Palliative sedation was defined as PS to unconsciousness (PSU), PS proportionate to symptoms (proportional palliative sedation [PPS]), or intermittent PS (IPS). Among 179 patients who died during 2012, PS was used among 21.2% (n = 38): (PSU 34.2%, PPS 34.2%, and IPS 31.6%), using midazolam (n = 33/38), halidol (21/38), and concurrent morphine (n = 35/38). Indications included agitation (71%), pain (36.8%), and dyspnea (21%). Survival following initiation of PS was 73 ± standard deviation 54 hours. No differences in survival were observed according to who initiated the decision to use PS (patients/medical staff/family) or type of PS (PSU/PPS/IPS). Survival following PS was longest with higher sedative doses, an observation that may help dispel fears concerning the use of PS to hasten death.

Keywords: end-of-life care; hospice; palliative care; palliative sedation; survival; terminal sedation.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid / administration & dosage
  • Antipsychotic Agents / administration & dosage
  • Female
  • Haloperidol / administration & dosage
  • Hospices / methods*
  • Hospices / statistics & numerical data
  • Humans
  • Hypnotics and Sedatives / administration & dosage*
  • Israel
  • Male
  • Midazolam / administration & dosage
  • Middle Aged
  • Morphine / administration & dosage
  • Pain / drug therapy
  • Palliative Care / methods*
  • Palliative Care / statistics & numerical data
  • Retrospective Studies
  • Terminal Care / methods*
  • Terminal Care / statistics & numerical data

Substances

  • Analgesics, Opioid
  • Antipsychotic Agents
  • Hypnotics and Sedatives
  • Morphine
  • Haloperidol
  • Midazolam